Working on OSH projects in the field of big industries 8energy, transport etc.) leads to face numerous challenges. These markets are usually characterized by important and powerful players dominating their markets at both national and global levels. Industrial activities are usually ruled with highly complex legislation as they face major risks. Users need to gain confidence of their supplier who must grant the highest security standards. The industrial actors play a systemic role in the global economy, the environmental footprint and world political balance. It is a must that socially concerned projects gain their place in such a strategic sector. Therefore, OSH startups need to play smart in order to succeed. Here we will find some of the key answers, applying powerful business techniques to real scenarios.